The emergence of disease-causing fungi that are resistant to antifungal drugs threatens both human health and food security, according to a recent paper. Some resistance has been found to every main class of agricultural fungicides and many medical antifungals used to treat humans and animals. The paper outlines some factors contributing to emerging resistance and makes some policy recommendations.
According to the paper, fungi currently cause yields losses of around 20% in crops, with a further 10% lost after harvest. Fungi are able to develop resistance to drugs quickly, because they reproduce rapidly and have genomes that frequently change. This can be worsened by factors such as monocultural cropping (which encourages the spread of resistant fungi), loss of plants’ abilities to defend themselves against fungi (inadvertently caused by selective breeding for yield rather than disease resistance, while protecting crops with “broad-scale pesticide applications”), and global trade in people and produce spreading pathogens.
The number of humans at risk of fungal infections is increasing because of a rise in vulnerable populations such as the elderly or immunocompromised people. Long term preventative treatment of these people with antifungals can encourage the emergence of antifungal resistance.
The paper recommends:
- Developing new antifungals, and using techniques such as “molecular modeling, combinatorial chemistry, and high-throughput screening” to hasten the process
- Using existing antifungals carefully, for example by using a mixture of antifungals that work in different ways to reduce the chances of resistance emerging
- Using alternative fungal control methods such as gene editing to develop fungi-resistant crops, human tissue engineering to reduce the vulnerability of patients receiving organ transplants, and developing treatments based on RNA interference.
The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. To avoid a global collapse in our ability to control fungal infections and to avoid critical failures in medicine and food security, we must improve our stewardship of extant chemicals, promote new antifungal discovery, and leverage emerging technologies for alternative solutions.
Fisher, M.C., Hawkins, N.J., Sanglard, D. and Gurr, S.J., 2018. Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science, 360(6390), pp.739-742.
Read the full paper here. The Foodsource resource Why does antibiotic resistance matter? discusses the separate but related issue of antibiotic resistance.
04 Jun 2018
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